2021
C. Favaretto, S. Spadone, C. Sestieri, V. Betti, A. Cenedese, S. Della Penna, M. Corbetta.
Multi-band MEG signatures of BOLD connectivity reorganization during visuospatial attention. Neuroimage, 2021
Abstract:
The functional architecture of the resting brain, as measured with the blood oxygenation level-dependent functional connectivity (BOLD-FC), is slightly modified during task performance. In previous work, we reported behaviorally relevant BOLD-FC modulations between visual and dorsal attention regions when subjects performed a visuospatial attention task as compared to central fixation (Spadone et al., 2015).
Here we use magnetoencephalography (MEG) in the same group of subjects to identify the electrophysiological correlates of the BOLD-FC modulation found in our previous work. While BOLD-FC topography, separately at rest and during visual attention, corresponded to neuromagnetic Band-Limited Power (BLP) correlation in the alpha and beta bands (8-30 Hz), BOLD-FC modulations evoked by performing the visual attention task (Spadone et al. 2015) did not match any specific oscillatory band BLP modulation. Conversely, following the application of an orthogonal spatial decomposition that identifies common inter-subject co-variations, we found that attention–rest BOLD-FC modulations were recapitulated by multi-spectral BLP-FC components. Notably, individual variability of alpha connectivity between Frontal Eye Fields and visual occipital regions, jointly with decreased interaction in the Visual network, correlated with visual discrimination accuracy. In summary, task-rest BOLD connectivity modulations match multi-spectral MEG BLP connectivity.
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2020
L. Meneghetti, M. Terzi, S. Del Favero, G.A. Susto, C. Cobelli.
Data-Driven Anomaly Recognition for Unsupervised Model-Free Fault Detection in Artificial Pancreas. IEEE Transactions on Control Systems Technology, vol. 28(1), pp. 33-47, 2020
Abstract:
The last decade has seen tremendous improvements in technologies for Type 1 Diabetes (T1D) management, in particular the so-called artificial pancreas (AP), a wearable closed-loop device modulating insulin injection based on glucose sensor readings. Unluckily, the AP actuator, an insulin pump, is subject to failures, with potentially serious consequences for subject safety. This calls for the development of advanced monitoring systems, leveraging the unprecedented data availability. This paper tackles for the first time the problem of automatically detecting pump faults with multidimensional data-driven anomaly detection (AD) methodologies. The approach allows to avoid the subtask of identifying a physiological model, typical of model-based approaches. Furthermore, we employ unsupervised methods, removing the need of labeled data for training, hardly available in practice. The adopted data-driven AD methods are local outlier factor, connectivity-based outlier factor, and isolation forest. Moreover, we propose a modification of these methods to cope with the dynamic nature of the underlying problem. The algorithms were tuned and tested on: 1) two-synthetic 100-patients' data set, of one-month data each, generated using the ``UVA/Padova T1D Simulator,'' a large-scale nonlinear computer simulator of T1D subject physiology, largely adopted in AP research and accepted by the American Food and Drug Administration as a replacement of preclinical animal trials for AP and 2) a real 7-patients' data set consisting of one month in free-living conditions. The satisfactory accuracy of the proposed approach paves the way to the embedding of these methodologies in AP systems or their deployment in remote monitoring systems.
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A. Razman, A. Majeed, R.M. Musa, Z. Taha, G.A. Susto, Y. Mukai.
Hyperparameter Tuning of the Model for Hunger State Classification. SpringerBriefs in Applied Sciences and Technology, pp. 49-57, 2020
Abstract:
To increase the classification, the rate of prediction based on existing models requires additional technique or in this case optimizing the model. Hyperparameter tuning is an optimization technique that evaluates and adjusts the free parameters that define the behaviour of classifiers. Data sets were classified practical with classifiers like SVM, k-NN, ANN and DA. To further improve the design efficiency, the secondary optimization level called hyperparameter tuning will be further investigated. DA, SVM, k-NN, decision tree (Tree), logistic regression (LR), random forest tree (RF) and neural network (NN) are evaluated. The k-NN provided 96.47% of the test sets with the best reliability in classifications. Bayesian optimization has been used to refine the hyperparameter; hence, standardize Euclidean distance metric with a k value of one is the ideal hyperparameters which could achieve classification performance of 97.16%.
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A. Razman, A. Majeed, R.M. Musa, Z. Taha, G.A. Susto, Y. Mukai.
Image Processing Features Extraction on Fish Behaviour. SpringerBriefs in Applied Sciences and Technology, pp. 25-36, 2020
Abstract:
This chapter demonstrates the pipeline from data collection until classifier models that achieve the best possible model in identifying the disparity between hunger states. The pre-processing segment describes the features of the data sets obtained by means of image processing. The method includes the simple moving average (SMA), downsizing factors, dynamic time warping (DTW) and clustering by the k-means method. This is to rationally assign the necessary significant information from the data collected and processed the images captured for demand feeder and fish motion as a synthesis for anticipating the state of fish starvation. The selection of features in this study takes place via the boxplot analysis and the principal component analysis (PCA) on dimensionality reduction. Finally, the validation of the hunger state will be addressed by comparing machine learning (ML) classifiers, namely the discriminant analysis (DA), support vector machine (SVM) and k-nearest neighbour (k-NN). The outcome in this chapter will validate the features from image processing as a tool for identifying the behavioural changes of the fish in school size.
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A. Razman, A. Majeed, R.M. Musa, Z. Taha, G.A. Susto, Y. Mukai.
Machine Learning in Aquaculture Hunger Classification of Lates calcarifer. 2020
Abstract:
This book highlights the fundamental association between aquaculture and engineering in classifying fish hunger behaviour by means of machine learning techniques. Understanding the underlying factors that affect fish growth is essential, since they have implications for higher productivity in fish farms. Computer vision and machine learning techniques make it possible to quantify the subjective perception of hunger behaviour and so allow food to be provided as necessary. The book analyses the conceptual framework of motion tracking, feeding schedule and prediction classifiers in order to classify the hunger state, and proposes a system comprising an automated feeder system, image-processing module, as well as machine learning classifiers. Furthermore, the system substitutes conventional, complex modelling techniques with a robust, artificial intelligence approach. The findings presented are of interest to researchers, fish farmers, and aquaculture technologist wanting to gain insights into the productivity of fish and fish behaviour.
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A. Razman, A. Majeed, R.M. Musa, Z. Taha, G.A. Susto, Y. Mukai.
Monitoring and Feeding Integration of Demand Feeder Systems. SpringerBriefs in Applied Sciences and Technology, pp. 11-24, 2020
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This chapter highlights the findings of the developmental monitoring systems for swimming pattern or motion analysis with regard to feeding behaviour. A benchmark for examining the framework on how scientists control fish in animal variable function factors was gathered and referred to gauge the adequate design in constructing a viable device. The validation of image processing and automated demand feeder to determine the results will also be considered, as a validation aspect between the system of tracking and the behaviour of the Lates calcarifer where the pixel intensity will be extracted as the features. The results of this chapter will enable the reader on the development of an integrated feeder scheme that consolidates surveillance scheme to identify the feeding behaviour and relation towards the specific growth rate (SGR).
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A. Razman, A. Majeed, R.M. Musa, Z. Taha, G.A. Susto, Y. Mukai.
Time-Series Identification on Fish Feeding Behaviour. SpringerBriefs in Applied Sciences and Technology, pp. 37-47, 2020
Abstract:
The identification of relevant parameters that could describe the state of fish hunger is vital for ensuring the appropriate allocation of food to the fish. The establishment of these relevant parameters is non-trivial, particularly when developing an automated demand feeder system. The present inquiry is being undertaken to determine the hunger state of Lates calcarifer. For data collection, a video analysis system is used, and the video was taken all day, where the fish was fed by an automatic feeding system. Sixteen characteristics of the raw data set have been extracted through feature engineering for 0.5 min, 1.0 min, 1.5 min and 2.0 min, respectively, in accordance with the mean, peak, minimum and variability of each of the different time window scales. Furthermore, the features extracted have been evaluated through principal component analysis (PCA) both for dimension reduction and PCA with varimax rotation. The details were then categorized using support vector machine (SVM), K-NN and random forest tree (RF) classifiers. The best identification accuracy was shown with eight described features in the varimax-based PCA. The forecast results based on the K-NN model built on selected data characteristics showed a level of 96.5% indicating that the characteristics analysed were crucial to classifying the actions of hunger among fisheries.
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2019
A. Razman, A.S.A. Ghani, A. Cenedese, F.A. Adnan, G.A. Susto, K.M. Ismail, R.M. Musa, Y. Mukai, Z. Taha, A. Majeed.
Hunger Classification of Lates Calcarifer by means of an automated feeder and image processing. Computers and Electronics in Agriculture, vol. 163, 2019
Abstract:
In an automated demand feeder system, underlining the parameters that contribute to fish hunger is crucial in order to facilitate an optimised food allocation to the fish. The present investigation is carried out to classify the hunger state of Lates calcarifer. A video surveillance technique is employed for data collection. The video was taken throughout the daytime, and the fish were fed through an automated feeding system. It was demonstrated through this investigation that the use of such automated system does contribute towards a higher specific growth rate percentage of body weight as well as the total length by approximately 26.00% and 15.00%, respectively against the conventional time-based method. Sixteen features were feature engineered from the raw dataset into window sizes ranging from 0.5?min, 1.0?min, 1.5?min and 2.0?min, respectively coupled with the mean, maximum, minimum and variance for each of the distinctive temporal window sizes. In addition, the extracted features were analysed through Principal Component Analysis (PCA) for dimensionality reduction as well as PCA with varimax rotation. The data were then classified using a Support Vector Machine (SVM), k-Nearest Neighbor (k-NN) and Random Forest Tree models. It was demonstrated that the varimax based PCA yielded the highest classification accuracy with eight identified features. The prediction results based of the developed k-NN model on the selected features on the test data exhibited a classification rate of 96.5% was achieved suggesting that the features examined are non-trivial in classifying the fish hunger behaviour.
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2018
C. Favaretto, A. Cenedese.
Non-linear modeling and control of Mitochondrial Dynamics. 57th IEEE Conference on Decision and Control (CDC 2018), pp. 3491--3496, 2018
Abstract:
Mitochondrial Dynamics (MD) has recently
emerged as one of the most interesting topics in biology since
the intricate connection between energy production and MD
regulates cells development and function. On the other hand,
the impairment of such mechanism is strictly related to the
emergence of various diseases, among which neurodegenerative
disorders. In this work, we provide a simple, yet complete, and
well-posed mathematical model to describe the MD and the
related phenomena through a population-dynamics approach,
together with the ATP-energy turnover, which is an important
step to unravel the underlying dynamics of the whole cell system
and has a key role in its quality control. With the tools of
system theory, we highlight the positiveness of the system and
the presence of non-zero equilibria and compute bounds for
the involved system state quantities. Furthermore, we consider
a situation of impairment in the MD and design a control law,
based on input-output linearization and state-feedback control
able to allow a damaged system to compensate for the defect and
behave as a nominal one. In this scenario, we test two different
protocols that could be suggestive for treatment strategies.
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